Irsogladine maleate regulates barrier function and neutrophil accumulation in the gingival epithelium

Publication date: May 2012 Source:Journal of Oral Biosciences, Volume 54, Issue 2 Author(s): Tsuyoshi Fujita , Hideki Shiba , Hidemi Kurihara Epithelial cells function as mechanical barriers against invasion by pathogenic organisms and promote intercellular communication through cell–cell junction complexes. Therefore, the permeability of the gingival epithelial cell layer indicates a defensive capability against invasion by periodontal pathogens. Accumulation of activated neutrophils is thought to be involved in the onset of inflammation. Here, we review the effects of irsogladine maleate, a medication for gastric ulcers, on E-cadherin and chemokine expression in gingival epithelial cells exposed to periodontopathogenic bacteria, in order to examine the clinical efficacy of irsogladine maleate in preventing periodontal inflammation. Highlights ► Irsogladine maleate has been used clinically as an anti-gastric ulcer agent. ► Irsogladine maleate regulates the neutrophil accumulation in gingival epithelium. ► Irsogladine maleate also controls barrier function in gingival epithelium. ► Irsogladine maleate may be useful for the prevention of periodontal inflammation.
Source: Journal of Oral Biosciences - Category: Biomedical Science Source Type: research