Adipose cells promote resistance of breast cancer cells to trastuzumab-mediated antibody-dependent cellular cytotoxicity
Conclusions:
Collectively, our findings underline the importance of adipose tissue in the resistance to trastuzumab, and suggest that approaches targeting the adipocyte-cancer cell crosstalk may help sensitize cancer cells to trastuzumab-based therapy.
Source: Breast Cancer Research - Category: Cancer & Oncology Authors: Minh DuongAurore CleretEva-Laure MateraKamel ChettabDoriane MathéSandrine Valsesia-WittmannBéatrice ClémenceauCharles Dumontet Source Type: research