In vivo patch-clamp analysis of the antinociceptive actions of TRPA1 activation in the spinal dorsal horn

Conclusions:
TRPA1 appears to be localized not only at presynaptic terminals on SG neurons, enhancing glutamate release, but also in the terminals of primary afferents innervating spinal inhibitory interneurons, which have synaptic interactions with SG neurons. This study offers further insight into the mechanisms underlying the possible antinociceptive actions of TRPA1 activation in the spinal dorsal horn. Our findings suggest that pharmacological activation of spinal TRPA1 channels may have therapeutic potential for the treatment of pain.

Source: Molecular Pain - April 21, 2015 Category: Molecular Biology Authors: Manabu YamanakaWataru TaniguchiNaoko NishioHiroshi HashizumeHiroshi YamadaMunehito YoshidaTerumasa Nakatsuka Source Type: research