Anoctamin 1 contributes to inflammatory and nerve-injury induced hypersensitivity

Conclusions:
In addition to ANO's role in mediating acute thermal pain as a heat sensor, ANO1 is also capable of augmenting the excitability of DRG neurons under inflammatory or neuropathic conditions and thereby aggravates inflammation- or tissue injury-induced pathological pain.

Source: Molecular Pain - January 23, 2014 Category: Molecular Biology Authors: Byeongjun LeeHawon ChoJooyoung JungYoung Duk YangDong-Jin YangUhtaek Oh Source Type: research