Group Sparsity Model for Stain Unmixing in Brightfield Multiplex Immunohistochemistry Images

Multiplex immunohistochemistry (IHC) staining is a new, emerging technique for the detection of multiple biomarkers within a single tissue section. The initial key step in multiplex IHC image analysis in digital pathology is of tremendous clinical importance due to its ability to accurately unmix the IHC image and differentiate each of the stains. The technique has become popular due to its significant efficiency and the rich diagnostic information it contains. The intriguing task of unmixing a three-channel CCD color camera acquired RGB image into more than three colors is very challenging, and to the best of our knowledge, hardly studied in academic literature.
Source: Computerized Medical Imaging and Graphics - Category: Radiology Authors: Source Type: research