Superparamagnetic iron oxide nanoparticles for in vivo molecular and cellular imaging

In the last decade, the biomedical applications of nanoparticles (NPs) (e.g. cell tracking, biosensing, magnetic resonance imaging (MRI), targeted drug delivery, and tissue engineering) have been increasingly developed. Among the various NP types, superparamagnetic iron oxide NPs (SPIONs) have attracted considerable attention for early detection of diseases due to their specific physicochemical properties and their molecular imaging capabilities. A comprehensive review is presented on the recent advances in the development of in vitro and in vivo SPION applications for molecular imaging, along with opportunities and challenges. Copyright © 2015 John Wiley & Sons, Ltd. Superparamagnetic iron oxide nanoparticles (SPIONs) have attracted considerable attention for diagnosis and early detection of diseases due to plenty of specific physicochemical attributes that make them suitable for molecular imaging applications. A comprehensive review is presented on recent advances in the development of in vitro and in vivo SPION applications for molecular imaging, along with opportunities and challenges.
Source: Contrast Media and Molecular Imaging - Category: Radiology Authors: Tags: Review Source Type: research