Vascular Endothelial Growth Factor Immunoexpression is Increased in Malignant Salivary Gland Tumors

Salivary gland tumors (SGTs) consist of a heterogeneous group of lesions accounting for 3% to 10% of all head and neck neoplasms. Little is known about their angiogenic properties and despite vascular endothelial growth factor (VEGF) has been previously studied in these lesions, further investigations are warranted to better determine its clinical and prognostic significance. In the current study a total of 132 formalin-fixed, paraffin-embedded SGTs were organized in tissue microarray blocks and submitted to immunohistochemistry against VEGF protein.

Source: Annals of Diagnostic Pathology - April 6, 2015 Category: Pathology Authors: Felipe Paiva Fonseca, Marcos Paulo Montanhana Basso, Fernanda Viviane Mariano, Luiz Paulo Kowalski, Márcio Ajudarte Lopes, Manoela Domingues Martins, Ana Lúcia Carrinho Ayroza Rangel, Alan Roger Santos-Silva, Pablo Agustin Vargas Tags: Original Contributions Source Type: research