The use of ketamine as an antidepressant: a systematic review and meta‐analysis

ConclusionsSingle ketamine infusions elicit a significant antidepressant effect from 4 h to 7 days; the small number of studies at 12–14 days post infusion failed to reach significance. Results suggest a discrepancy in peak response time depending upon primary diagnosis — 24 h for MDD and 7 days for BD. The majority of published studies have used pre–post comparison; further placebo‐controlled studies would help to clarify the effect of ketamine over time. Copyright © 2015 John Wiley & Sons, Ltd.
Source: Human Psychopharmacology: Clinical and Experimental - Category: Psychiatry Authors: Tags: Review Article Source Type: research